Agmatine Sulfate

CAS Number: 2482-00-0
Molecular Weight: 228.27
Molecular Formula: C5H14N4H2SO4
Physical Appearance: White to off-white powder

PRODUCT USE

Derivative of decarboxylated arginine. Agmantine has been isolated from ergot, sponges, octupus muscle, herring sperm and

from the pollen of Ambrosia artemisifolia L., Compositae. Putative endogenous neurotransmitter at imidazoline receptors; a

clonidine-displacing substance.

DESCRIPTION

Agmatine sulfate is the sulfate preparation of Agmatine, the decarboxylated form of L-arginine and an endogenous metabolic product highly conserved across life forms. Agmatine is an intermediate in the biosynthesis of the polyamines putrecine and spermine. Agmatine binds with high affinity to α2-adrenergic receptors and imidazoline binding sites and produces blockade of the NMDA-receptor associated cation channels. The further observations that Agmatine is also stored in synaptic vesicles, is specifically degraded by agmatinase, and is released from axon terminals by depolarization all suggest that Agmatine has endogenous function as a neurotransmitter. Agmatine is a competitive inhibitor of NOS (nitric oxide synthase) activity owing to mimicry of the natural NOS substrate arginine.

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